hudson, w. h. et al. proliferating transitory t cells with an effector-like transcriptional signature emerge from pd-1 stem-like cd8 t cells during chronic infection. immunity 51, 1043–1058.e4 (2019).

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14-09-2022
Biology

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hudson, w. h. et al. proliferating transitory t cells with an effector-like transcriptional signature emerge from pd-1 stem-like cd8 t cells during chronic infection. immunity 51, 1043–1058.e4 (2019).

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Tutorconsortium358 Tutorconsortium358 · Answer 1 · 2022-09-18T16:03:05+02:00

T cell failure is a defining trait of both cancer and persistent viral infections. A PD-1+ Tcf-1+ CD8+ T cell subset with the ability to self-renew and differentiate into more terminally differentiated cells that downregulate Tcf-1 and express additional inhibitory molecules like Tim3 has been identified in recent studies of chronic lymphocytic choriomeningitis virus (LCMV) infection.

Here, we show that this terminally differentiated population is divided into two subgroups by the expression of the glycoprotein CD101.
Initially differentiating into a transitory population of CD101-Tim3+ cells, stem-like Tcf-1+ CD8+ T cells later transformed into CD101+ Tim3+ cells.
Recent CD101-Tim3+ cell proliferation in vivo, viral control, and expression of the chemokine receptor CX3CR1, pro-inflammatory cytokines, and granzyme B are all characteristics of these effector-like cells.
Increased CD101-Tim3+ CD8+ T cell counts in response to PD-1 pathway inhibition raise the possibility that these recently formed transitional cells are essential for PD-1-based immunotherapy.

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