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Which of the following outcomes is observed during Rabies virus pathogenesis?

a) Rabies virus replicates rapidly in muscle cells prior to traveling to the peripheral and central nervous systems.
b) Rabies virus causes infected muscle cells to rupture after viral infection and replication.
c) Negri bodies are a diagnostic sign of Rabies virus infection.
d) Administration of post-exposure prophylaxis after the development of neurological symptoms is an effective way to limit progression of rabies viral illness.

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Answer:

c) Negri bodies are a diagnostic sign of Rabies virus infection.

Explanation:

Rabies is an infection caused by rabies virus which affects the neurons and causes inflammation of the brain. It is a deadly disease and many animals are carriers of this disease like dogs, cats, raccoons, wolf, bats, fox, etc.  

It is diagnosed by the presence of Negri bodies in the cytoplasm of nerve cells. Negri bodies are inclusions that are round or oval shapes having a size between 0.25 to 27 μm. Negri bodies can be frequently diagnosed in Purkinje cells of the cerebellum and pyramidal cells of Ammon’s horn.  

Apart from these cells, they can be found in various ganglia, neurons of the tongue and other organs. So the correct answer is c.

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